Evaluation of the role of mico-RNAs in cardiomyocytes differentiation of mesenchymal stem cells

Stem cells are a good alternative for regenerative medicine because of their characteristics such as self-renewal and differentiation potential. They are classified into different types of stem cells including embryonic stem cells, induced pluripotent stem cells, multipotent stem cells, and ultimately uni-potent stem cells. Mesenchymal stem cells extracted from adult tissues. Due to the lack of graft loss, they are an appreciate option for cell therapy, especially ischemic heart disease. Micro-RNAs are a group of small non-coding RNAs that are evolutionarily conserved. They have participated in various cellular processes such as cell cycle regulation, apoptosis, regulation of stemness, especially the cardiomyocytes differentiation of mesenchymal stem cells and regulation of different signaling pathways involved in differentiation. Many miRNAs are expressed in various tissues; they can be used as biomarkers in the diagnosis of certain diseases. Also, mi-RNAs have been studied more than other types of non-coding RNAs. Our review summarizes the vital role of microRNAs in the cardiomyocytes differentiation of mesenchymal stem cells